Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2

J Med Chem. 1994 Mar 4;37(5):557-9. doi: 10.1021/jm00031a001.

Authors

H G Beaton¹, C Bennion, S Connolly, A R Cook, N P Gensmantel, C Hallam, K Hardy, B Hitchin, C G Jackson, D H Robinson

Affiliation

¹ Department of Medicinal Chemistry, Fisons plc, Loughborough, Leicestershire, U.K.

PMID: 8126692
DOI: 10.1021/jm00031a001

No abstract available

MeSH terms

Animals
Benzhydryl Compounds / chemistry*
Benzhydryl Compounds / pharmacology
Binding Sites
Blood Platelets / enzymology
Drug Design
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Pancreas / enzymology
Phospholipases A / antagonists & inhibitors*
Phospholipases A / metabolism
Structure-Activity Relationship
Swine
gamma-Aminobutyric Acid / analogs & derivatives*
gamma-Aminobutyric Acid / chemistry
gamma-Aminobutyric Acid / pharmacology

Substances

Benzhydryl Compounds
FPL 67047XX
gamma-Aminobutyric Acid
Phospholipases A